The NHS is creating a new national database to help identify people who may be genetically at higher risk of developing cancer, offering earlier screening and more personalised care.
The register will bring together genetic information linked to 120 genes known to increase the likelihood of cancer.
By comparing patients’ genetic data with the database, doctors will be able to identify those with inherited risks and offer regular check-ups and targeted screening for cancers such as breast and prostate cancer.
Patients may also benefit from treatments tailored to their genetic profile, helping doctors decide which therapies are likely to work best.
Health Secretary Wes Streeting described the initiative as “life-changing and life-saving”, saying it would help cancers be detected earlier and treated more effectively.
Each year, tens of thousands of people with cancer or a family history of the disease already undergo genetic testing on the NHS. Those found to have a higher risk will now be added to the new register and given clear advice on how to reduce their risk or spot symptoms early.
The database is part of the NHS’s 10-year plan to strengthen cancer prevention and care. Professor Peter Johnson, NHS England’s national cancer director, said it was the first time a healthcare system had brought all cancer-related genetic risk information into one secure place.
He said the register would allow clinicians to keep in touch with high-risk patients, offering new screening options or preventative treatments as they become available, while ensuring strict confidentiality.
The model builds on the success of a similar database for Lynch syndrome, which has already helped thousands access early screening.
Cancer charities have welcomed the move, saying it could significantly improve outcomes for people with inherited cancer risks.
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